KMID : 1237720140470020111
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Anatomy & Cell Biology 2014 Volume.47 No. 2 p.111 ~ p.116
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Change of peroxisome proliferator-activated receptor ¥ã expression pattern in the gerbil dentate gyrus after transient global cerebral ischemia
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Lee Choong-Hyun
Won Moo-Ho
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Abstract
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Peroxisome proliferator-activated receptor ¥ã (PPAR¥ã) has various actions including the regulation of adipocyte differentiation, lipid metabolism and glucose homeostasis. In the present study, we examined the changes of PPAR¥ã immunoreactivity and protein levels in the gerbil dentate gyrus (DG) after transient global cerebral ischemia using immunohistochemistry and western blot analysis. PPAR¥ã immunoreactivity was gradually increased from 1 day after ischemia-reperfusion. PPAR¥ã immunoreactivity, in accordance with protein level, was highest at 2 days after ischemia-reperfusion and was detected in microglia at this time. Thereafter, both PPAR¥ã immunoreactivity and protein level were decreased with time in the ischemic DG. These results indicate that PPAR¥ã may be related to the ischemia-induced microglial activation and neuronal damage/death in the DG after transient global cerebral ischemia.
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KEYWORD
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PPAR gamma, Ischemia-reperfusion, Dentate gyrus, Microglia
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